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1

MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL

Schwartz, Thue W., Frimurer, Thomas M., Holst, Birgitte, Rosenkilde, Mette M., Elling, Christian E.

Journal:

Annual Review of Pharmacology

Year:

2006

Language:

english

File:

PDF, 1006 KB

english, 2006

2

Pharmacokinetics of high-dose intravenous melatonin in humans

Andersen, Lars P. H., Werner, Mads U., Rosenkilde, Mette M., Fenger, Andreas Q., Petersen, Marian C., Rosenberg, Jacob, Gögenur, Ismail

Journal:

Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 170 KB

english, 2016

3

Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents

Gasbjerg, Lærke Smidt, Gabe, Maria Buur Nordskov, Hartmann, Bolette, Christensen, Mikkel Bring, Knop, Filip Krag, Holst, Jens Juul, Rosenkilde, Mette Marie

Journal:

Year:

2018

Language:

english

File:

PDF, 595 KB

english, 2018

4

Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists

Gasbjerg, Lærke S., Bergmann, Natasha C., Stensen, Signe, Christensen, Mikkel B., Rosenkilde, Mette M., Holst, Jens J., Nauck, Michael, Knop, Filip K.

Journal:

Year:

2019

Language:

english

File:

PDF, 2.95 MB

english, 2019

5

Glucose-Dependent Insulinotropic Polypeptide Augments Glucagon Responses to Hypoglycemia in Type 1 Diabetes

Christensen, Mikkel, Calanna, Salvatore, Sparre-Ulrich, Alexander H., Kristensen, Peter L., Rosenkilde, Mette M., Faber, Jens, Purrello, Francesco, van Hall, Gerrit, Holst, Jens J., Vilsbøll, Tina, Kn

Journal:

Year:

2015

Language:

english

File:

PDF, 987 KB

english, 2015

6

Identification and Functional Comparison of Seven-Transmembrane G-Protein-Coupled BILF1 Receptors in Recently Discovered Nonhuman Primate Lymphocryptoviruses

Spiess, Katja, Fares, Suzan, Sparre-Ulrich, Alexander H., Hilgenberg, Ellen, Jarvis, Michael A., Ehlers, Bernhard, Rosenkilde, Mette M., Sandri-Goldin, R. M.

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 4.49 MB

english, 2015

7

The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine

Pedersen, Jens, Pedersen, Nis B., Brix, Sophie W., Grunddal, Kaare Villum, Rosenkilde, Mette M., Hartmann, Bolette, Ørskov, Cathrine, Poulsen, Steen S., Holst, Jens J.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.73 MB

english, 2015

8

The role of endogenous GIP and GLP-1 in postprandial bone homeostasis

Helsted, Mads M., Gasbjerg, LÃ¦rke S., Lanng, Amalie R., Bergmann, Natasha C., Stensen, Signe, Hartmann, Bolette, Christensen, Mikkel B., Holst, Jens J., VilsbÃ¸ll, Tina, Rosenkilde, Mette M., Knop, F

Journal:

Year:

2020

File:

PDF, 1.03 MB

2020

9

The Dual GLP-1/GIP Receptor Agonist DA4-JC Shows Superior Protective Properties Compared to the GLP-1 Analogue Liraglutide in the APP/PS1 Mouse Model of Alzheimerâs Disease

Maskery, Mark, Goulding, Elizabeth Mary, Gengler, Simon, Melchiorsen, Josefine Ulrikke, Rosenkilde, Mette Marie, HÃ¶lscher, Christian

Journal:

American Journal of Alzheimer's Disease and Other Dementias

Year:

2020

File:

PDF, 933 KB

2020

10

Microbiological exploitation of the chemokine system

Peter J. Holst, Mette M. Rosenkilde

Journal:

Microbes and Infection

Year:

2003

Language:

english

File:

PDF, 182 KB

english, 2003

11

The chemokine system – a major regulator of angiogenesis in health and disease

METTE M. ROSENKILDE, THUE W. SCHWARTZ

Journal:

Year:

2004

Language:

english

File:

PDF, 370 KB

english, 2004

12

How Receptor Mutagenesis May Confirm or Confuse Receptor Classification

THUE W. SCHWARTZ, SIGNE PERLMAN, METTE M. ROSENKILDE, SIV A. HJORTH

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.24 MB

english, 1997

13

Virally encoded 7TM receptors

Rosenkilde, Mette M, Waldhoer, Maria, Lüttichau, Hans R, Schwartz, Thue W

Journal:

Year:

2001

Language:

english

File:

PDF, 670 KB

english, 2001

14

AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

Sigrid Hatse, Katrien Princen, Erik De Clercq, Mette M. Rosenkilde, Thue W. Schwartz, Pedro E. Hernandez-Abad, Renato T. Skerlj, Gary J. Bridger, Dominique Schols

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 341 KB

english, 2005

15

Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74

Katherine A McLean, Peter J Holst, Lene Martini, Thue W Schwartz, Mette M Rosenkilde

Journal:

Year:

2004

Language:

english

File:

PDF, 622 KB

english, 2004

16

Modulation in Selectivity and Allosteric Properties of Small-Molecule Ligands for CC-Chemokine Receptors

Thiele, Stefanie, Malmgaard-Clausen, Mikkel, Engel-Andreasen, Jens, Steen, Anne, Rummel, Pia C., Nielsen, Mads C., Gloriam, David E., Frimurer, Thomas M., Ulven, Trond, Rosenkilde, Mette M.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.67 MB

english, 2012

17

Rational Design of Conformationally Constrained Cyclopentapeptide Antagonists for C-X-C Chemokine Receptor 4 (CXCR4)

Mungalpara, Jignesh, Thiele, Stefanie, Eriksen, Øystein, Eksteen, Johann, Rosenkilde, Mette M., Våbenø, Jon

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 331 KB

english, 2012

18

Porcine glucagon-like peptide-2: Structure, signaling, metabolism and effects

Nis B. Pedersen, Karina R. Hjollund, Anders H. Johnsen, Cathrine Ørskov, Mette M. Rosenkilde, Bolette Hartmann, Jens J. Holst

Journal:

Regulatory Peptides

Year:

2008

Language:

english

File:

PDF, 761 KB

english, 2008

19

Ligand binding and micro-switches in 7TM receptor structures

Rie Nygaard, Thomas M. Frimurer, Birgitte Holst, Mette M. Rosenkilde, Thue W. Schwartz

Journal:

Trends in Pharmacological Sciences

Year:

2009

Language:

english

File:

PDF, 1.11 MB

english, 2009

20

The minor binding pocket: a major player in 7TM receptor activation

Mette M. Rosenkilde, Tau Benned-Jensen, Thomas M. Frimurer, Thue W. Schwartz

Journal:

Trends in Pharmacological Sciences

Year:

2010

Language:

english

File:

PDF, 652 KB

english, 2010

21

GPR119 as a fat sensor

Harald S. Hansen, Mette M. Rosenkilde, Jens J. Holst, Thue W. Schwartz

Journal:

Trends in Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 736 KB

english, 2012

22

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

Sigrid Hatse, Katrien Princen, Kurt Vermeire, Lars-Ole Gerlach, Mette M. Rosenkilde, Thue W. Schwartz, Gary Bridger, Erik De Clercq, Dominique Schols

Journal:

Year:

2003

Language:

english

File:

PDF, 497 KB

english, 2003

23

Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

Mette M Rosenkilde, Maria Lucibello, Birgitte Holst, Thue W Schwartz

Journal:

Year:

1998

Language:

english

File:

PDF, 354 KB

english, 1998

24

Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28

Thomas N Kledal, Mette M Rosenkilde, Thue W Schwartz

Journal:

Year:

1998

Language:

english

File:

PDF, 427 KB

english, 1998

25

Virus-encoded chemokine receptors – putative novel antiviral drug targets

Mette M. Rosenkilde

Journal:

Neuropharmacology

Year:

2005

Language:

english

File:

PDF, 847 KB

english, 2005

26

Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

Hannelouise Kissow, Bolette Hartmann, Jens Juul Holst, Niels-Erik Viby, Lærke Schmidt Hansen, Mette Marie Rosenkilde, Kristine Juul Hare, Steen Seier Poulsen

Journal:

Regulatory Peptides

Year:

2012

Language:

english

File:

PDF, 1.10 MB

english, 2012

27

Multistep Continuous-Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure-Activity Relationships of CCR8 Ligands

Petersen, Trine P., Mirsharghi, Sahar, Rummel, Pia C., Thiele, Stefanie, Rosenkilde, Mette M., Ritzén, Andreas, Ulven, Trond

Journal:

Chemistry - A European Journal

Year:

2013

Language:

english

File:

PDF, 696 KB

english, 2013

28

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

Hansen, Katrine B., Rosenkilde, Mette M., Knop, Filip K., Wellner, Niels, Diep, Thi A., Rehfeld, Jens F., Andersen, Ulrik B., Holst, Jens J., Hansen, Harald S.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2011

Language:

english

File:

PDF, 993 KB

english, 2011

29

Structure–Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

Chalikiopoulos, Alexander, Thiele, Stefanie, Malmgaard-Clausen, Mikkel, Rydberg, Patrik, Isberg, Vignir, Ulven, Trond, Frimurer, Thomas M., Rosenkilde, Mette M., Gloriam, David E.

Journal:

Journal of Chemical Information and Modeling

Year:

2013

Language:

english

File:

PDF, 3.67 MB

english, 2013

30

Small molecule antagonism of oxysterol-induced Epstein–Barr virus induced gene 2 (EBI2) activation

Benned-Jensen, Tau, Madsen, Christian M., Arfelt, Kristine N., Smethurst, Christian, Blanchard, Andy, Jepras, Robert, Rosenkilde, Mette M.

Journal:

Year:

2013

Language:

english

File:

PDF, 649 KB

english, 2013

31

Molecular mechanism of activation and inhibition of 7TM peptide receptors

Schwartz, Thue W., Hjorth, Siv A., Elling, Christian, Nielsen, Søren Møller, Gether, Ulrik, Rosenkilde, Mette M., Zoffmann, Sannah, den Hollander, Roos, Schambye, Hans T., Perlmann, Signe

Journal:

European Journal of Pharmaceutical Sciences

Year:

1994

Language:

english

File:

PDF, 209 KB

english, 1994

32

The CCR5 Receptor Acts as an Alloantigen in CCR5Δ 32 Homozygous Individuals: Identification of Chemokine-and HIV-1-Blocking Human Antibodies

Henrik J. Ditzel, Mette M. Rosenkilde, Peter Garred, Meng Wang, Klaus Koefoed, Court Pedersen, Dennis R. Burton and Thue W. Schwartz

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.31 MB

english, 1998

33

Phorbol Esters and SDF-1 Induce Rapid Endocytosis and down Modulation of the Chemokine Receptor CXCR4

Natalie Signoret, Joanne Oldridge, Annegret Pelchen-Matthews, Per J. Klasse, Thanh Tran, Lawrence F. Brass, Mette M. Rosenkilde, Thue W. Schwartz, William Holmes, Walt Dallas, Michael A. Luther, Timot

Journal:

The Journal of Cell Biology

Year:

1997

Language:

english

File:

PDF, 1.82 MB

english, 1997

34

Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

Zachariassen, Zack G., Thiele, Stefanie, Berg, Erik A., Rasmussen, Pernille, Fossen, Torgils, Rosenkilde, Mette M., Våbenø, Jon, Haug, Bengt Erik

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 899 KB

english, 2014

35

Metal Ion Enhanced Binding of AMD3100 to Asp 262 in the CXCR4 Receptor †

Gerlach, Lars Ole, Jakobsen, Janus S., Jensen, Kasper P., Rosenkilde, Mette R., Skerlj, Renato T., Ryde, Ulf, Bridger, Gary J., Schwartz, Thue W.

Journal:

Year:

2003

Language:

english

File:

PDF, 329 KB

english, 2003

36

Identification and Characterization of Small Molecule Modulators of the Epstein–Barr Virus-Induced Gene 2 (EBI2) Receptor

Gessier, Francois, Preuss, Inga, Yin, Hong, Rosenkilde, Mette M., Laurent, Stephane, Endres, Ralf, Chen, Yu A., Marsilje, Thomas H., Seuwen, Klaus, Nguyen, Deborah G., Sailer, Andreas W.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 549 KB

english, 2014

37

Structure–activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists

Mungalpara, Jignesh, Zachariassen, Zack G., Thiele, Stefanie, Rosenkilde, Mette M., Våbenø, Jon

Journal:

Organic & Biomolecular Chemistry

Year:

2013

Language:

english

File:

PDF, 1020 KB

english, 2013

38

Oxysterol-EBI2 signaling in immune regulation and viral infection

Daugvilaite, Viktorija, Arfelt, Kristine Niss, Benned-Jensen, Tau, Sailer, Andreas W., Rosenkilde, Mette M.

Journal:

European Journal of Immunology

Year:

2014

Language:

english

File:

PDF, 658 KB

english, 2014

39

Biased and G Protein-Independent Signaling of Chemokine Receptors

Steen, Anne, Larsen, Olav, Thiele, Stefanie, Rosenkilde, Mette M.

Journal:

Frontiers in Immunology

Year:

2014

Language:

english

File:

PDF, 5.67 MB

english, 2014

40

High Content Screening for G Protein-Coupled Receptors Using Cell-Based Protein Translocation Assays

Granas, Charlotta, Lundholt, Betina, Heydorn, Arne, Linde, Viggo, Pedersen, Hans-Christian, Krog-Jensen, Christian, Rosenkilde, Mette, Pagliaro, Len

Journal:

Combinatorial Chemistry & High Throughput Screening

Year:

2005

Language:

english

File:

PDF, 444 KB

english, 2005

41

Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists

Våbenø, Jon, Haug, Bengt Erik, Rosenkilde, Mette M

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.48 MB

english, 2015

42

The anorexic hormone Peptide YY 3–36 is rapidly metabolized to inactive Peptide YY 3–34 in vivo

Toräng, Signe, Veedfald, Simon, Rosenkilde, Mette Marie, Hartmann, Bolette, Holst, Jens Juul

Journal:

Physiological Reports

Year:

2015

Language:

english

File:

PDF, 358 KB

english, 2015

43

Probing the Molecular Interactions Between CXC Chemokine Receptor 4 (CXCR4) and an Arginine-Based Tripeptidomimetic Antagonist (KRH-1636)

Zachariassen, Zack Georg, Karlshøj, Stefanie, Haug, Bengt Erik, Rosenkilde, Mette M., Våbenø, Jon

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.25 MB

english, 2015

44

Molecular Mechanism of AMD3100 Antagonism in the CXCR4 Receptor

Rosenkilde, Mette M., Gerlach, Lars-Ole, Jakobsen, Janus S., Skerlj, Renato T., Bridger, Gary J., Schwartz, Thue W.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 1.22 MB

english, 2004

45

Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

Andersen, Lars P. H., Werner, Mads U., Rosenkilde, Mette M., Harpsøe, Nathja G., Fuglsang, Hanne, Rosenberg, Jacob, Gögenur, Ismail

Journal:

BMC Pharmacology and Toxicology

Year:

2016

Language:

english

File:

PDF, 537 KB

english, 2016

46

Vasopressin receptors V1 a and V2 are not osmosensors

Lykke, Kasper, Assentoft, Mette, Fenton, Robert A., Rosenkilde, Mette M., MacAulay, Nanna

Journal:

Physiological Reports

Year:

2015

Language:

english

File:

PDF, 429 KB

english, 2015

47

The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo

Toräng, Signe, Veedfald, Simon, Rosenkilde, Mette Marie, Hartmann, Bolette, Holst, Jens Juul

Journal:

Year:

2016

Language:

english

File:

PDF, 57 KB

english, 2016

48

In vivo and in vitro degradation of peptide YY 3–36 to inactive peptide YY 3–34 in humans

Toräng, Signe, Bojsen-Møller, Kirstine Nyvold, Svane, Maria Saur, Hartmann, Bolette, Rosenkilde, Mette Marie, Madsbad, Sten, Holst, Jens Juul

Journal:

AJP Regulatory Integrative and Comparative Physiology

Year:

2016

Language:

english

File:

PDF, 1.66 MB

english, 2016

49

Targeting Herpesvirus Reliance of the Chemokine System

Rosenkilde, Mette, Kledal, Thomas

Journal:

Current Drug Targets

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

50

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

Barington, Line, Rummel, Pia C., Lückmann, Michael, Pihl, Heidi, Larsen, Olav, Daugvilaite, Viktorija, Johnsen, Anders H., Frimurer, Thomas M., Karlshøj, Stefanie, Rosenkilde, Mette M.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 2.56 MB

english, 2016